Life after antibiotics
Antibiotics have been widely used in animal production for many years now, mainly for therapeutic purposes, additionally for prophylaxis, and finally as a growth promoter in sub-therapeutic dosages. In accordance of the Principle 15 of the Rio Declaration of 1992, which arbours the idea, “Where there are threats of serious or irreversible damage, lack of full scientific certainty, shall not be used as a reason for postponing cost-effective measures to prevent environmental degradation”, first the developed European countries such as Sweden, and following that the whole European Union area, have banned the use of antibiotic growth promoters, and also have limited the use of molecules that are relevant to human health, in livestock. Finally this year USA has joined the regulation and as well as Far East countries such as Thailand, Indonesia, etc. also are following a strong projection of decreasing the antibiotic usage in general. This positive approach, of course, brings a certain responsibility of such as improving the biosecurity, enhancing management measures, focusing on nutrition, the handling of the digestive tract, the use of functional additives, whilst most important of them focusing on tissue integrity, immunity, reducing oxidative stress, and also aiming to decrease as much as possible the bacterial load, that will be shed to the environment.
Reducing antibiotic resistance with monoglycerides and free fatty acids
Antimicrobials have been used in animal feed for about 70 years to treat diseases, boost growth and obtain improvement in productivity (FAO 2018). Use of antibiotics to promote animal growth has been banned in European Union (EU) since January 1, 2006. Europe has done it and USA is in progress. Antimicrobial resistance remains a serious threat to public health worldwide. European Centre for Disease Prevention and Control, Stockholm, 2017 (ECDC 2017) from many European countries is reported that high percentages of isolates with resistance to key antimicrobial groups still exist which shows great concern and represent a serious threat to patient safety. Overview of the annual morbidity and mortality of antibiotic-resistant infections in the United States, estimating their number at approximately 2 million and the number of death associated with these infections at 23,000 (CDC 2013). Antibiotic Growth Promoters are still used as feed additives in countries outside EU. A radical rethinking of policies to reduce antibiotic consumption and resistant is necessary worldwide.
Less antibiotics with Phytogenics support
Antimicrobial drugs play an important role in the treatment of diseases in human and animals. Misusing antimicrobial drugs will increase the potential risk of spreading antimicrobial resistance and vital medicines will fail when bacteria become resistant to them (FAO, 2018). To combat microbial resistance many studies have been investigating alternative environmental friendly antimicrobial agents from various sources.
Essential oils (Eos) and less antibiotics:
Essential Oils (EOs) are concentrated natural products with a strong smell which are produced by aromatic plants (different part of herbs) as secondary metabolites. They enhance production of digestive secretions, stimulate blood circulation, exert antioxidant properties, reduce levels of pathogenic bacteria and may enhance immune status (Brenes and Roura, 2010). They have a small proportion of a wet weight of plant material and extracting methods would cause different activities of different EOs (Bouhaddouda et al., 2016). EOs activities as alternatives to antibiotics have been investigated and various researchers have studied on different essential oils as alternatives to antibiotics. They have been playing a very important role to cope antibiotic resistant threat. EOs have different compounds varied in their exact chemical composition and concentration due to factors such as seasonal variation, climate, and oil-extraction method (Santoyo et al., 2006). Mathlouthi N, et al., 2012 found that rosemary and oregano oil resulted in the same amount of growth in chickens as the antibiotic avilamycin, and the oils killed bacteria too. EOs could also reduce salmonella in chickens (Cerisuelo A, et al., 2014).
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